Signaux Wnt4/Frizzled6 non canoniques dans le développement myéloïde normal et leucémique

 

Krista Heinonen

Institut national de la recherche scientifique

 

Domaine : maladies infectieuses et immunitaires

Programme chercheurs-boursiers - Junior 1

Concours 2015-2016

All cells of the adult immune system are derived from a small number of bone marrow hematopoietic stem cells (HSC). In addition to being able to develop into the different blood cell lineages, HSC also have the unique capacity to self-renew. The number of HSCs is tightly regulated and unbalanced proliferation and differentiation can lead to multiple immune-related illnesses, such as inflammatory diseases, autoimmunity, immune deficiency and cancer (leukemias and lymphomas).

HSC interaction with the bone marrow microenvironment is necessary for their self-renewal. These interactions are often altered in the case of leukemias, for example. On the other hand, one of the technical challenges in the field is to develop methods for stem cell expansion in culture while limiting the loss of their self-renewal capacity. We propose to study the role of Wnt signaling in the regulation of HSC interactions with the surrounding stromal cells. These studies should advance our understanding of HSC biology, with the ultimate objective to identify new molecules to support HSC expansion and to develop new therapeutical targets for adult and pediatric leukemia.