Nouveaux déterminants moléculaires des maladies métaboliques associées au vieillissement

Chercheurs-boursiers- Senior | Concours 2012-2013


Frédéric Picard

Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec

 

Domaine : Vieillissement

The demography of the Canadian population is shifting robustly and rapidly towards a higher proportion of older people. Because aging increases vulnerability to pathologies, the rate of age-related health complications is also increasing, along with the growing economic costs that the treatment of these diseases has generated. Thus, the search for the fundamental causes of age-related disorders is crucial. The present proposal aims at testing possible causes of fat accumulation and heart failure. We believe that changes in the levels of specific genes are crucial for the development adipose tissue, glucose intolerance, and heart failure. The main objective of this proposal is to determine whether specific genes, found through our genomic discovery platform, can impact on fat accumulation, glucose homeostasis and cardiac function upon aging in mice. We will use young and old mice as model for age-induced metabolic diseases. We will also use mice that lack a specific gene and we will study their fat and heart to test whether it functions the same as regular mice. If we obtain positive results, we will further test our hypothesis on human cardiac cells obtained donor patients. Our project is unique and very innovative, since we will use mouse and human models coupled with physiological and molecular approaches, which will provide very powerful experimental designs and allow meaningful conclusions. We believe that the discoveries obtained from this grant will go towards the development of therapeutic solutions for age-induced metabolic diseases.