Modèles pronostiques pour l'apparition de symptômes respiratoires au travail et d'un déclin anormal de la fonction respiratoire chez les individus exposés à des agents sensibilisants au travail

 

Eva Suarthana

Centre de recherche de l'Hôpital du Sacré-Coeur de Montréal

 

Domaine : santé des populations

Programme  Bourses de carrière FRQ - IRSST en santé et en sécurité du travail

Concours 2015-2016

The main objective of this research program is to evaluate the long-term respiratory effects of exposure to occupational sensitizing agents. Since 1993, researchers at the Hôpital du Sacré-Coeur de Montréal have carried out inception cohorts of apprentices in pastry-making, dental hygiene, animal technology, carpainting and welding professions. Long-term post-apprenticeship follow-ups were completed in the first four cohorts. To fulfill the main objective, the applicant will conduct three projects. Project 1: to carry out long-term follow-up of the cohort of 247 former apprentices in welding profession, 7-12 years after the end of the apprenticeship, to the same extent as the four other cohorts.

The objective is to evaluate doseresponse relationships between post-apprenticeship exposure to welding fumes and work-related respiratory symptoms, as well as excessive decline in respiratory function (i.e. primary outcomes). Work productivity and activity impairment will be evaluated as secondary outcomes. Project 2: to develop prognostic models for the occurrence of work-related respiratory symptoms and excessive decline in respiratory function in five Quebec cohorts of former apprentices (i.e. development population). Project 3: to validate the models for excessive decline in lung function in a general population-based cohort (i.e. validation population) in Switzerland. Trained research assistants will administer questionnaires, spirometry, and methacholine bronchial challenge tests. Two independent occupational hygienists will evaluate exposure to welding fumes. For Project 1, incidence of the primary outcomes post-apprenticeship will be estimated. Dose-response relationships will be analyzed using logistic regression. For Project 2 and Project 3, prognostic models will be developed and validated using standard techniques.

This will be the first study to assess long-term respiratory effects of exposure to welding fumes. The proposed prognostic models may facilitate secondary prevention by targeting advanced tests and interventions to subjects who are likely to develop work-related respiratory symptoms and/or excessive respiratory function decline.