Le sommeil et la cognition dans les maladies neurodégénératives

Chercheurs-boursiers-Junior 2 | Concours 2012-2013


Jean-François Gagnon

Centre de recherche de l'Hôpital du Sacré-Coeur de Montréal

 

Domaine : Vieillissement

REM sleep behavior disorder is a condition characterized by undesirable and often violent behaviors during sleep. These episodes are strongly associated with dream content. They disrupt sleep and can seriously harm the patient and/or the bed partner. REM sleep behavior disorder concerns approximately 1% of general population and generally appears in men after the age of 50. We observed that a significant amount of patients with REM sleep behavior disorder developed a neurodegenerative disease such as Parkinson's disease after a few years. Moreover, we observed that half of these patients presented preclinical markers of Parkinson's disease. The aim of the present research program is to undertake a follow-up of these patients in order to define the evolution pattern of the disease and to identify subjects at risk of developing Parkinson's disease. A second aim is to identify brain regions involved in the disease. This research opens the door to new therapeutic approaches in order to not only decrease abnormal behaviors during sleep but above all to prevent or delay the onset of worse neurological diseases such as Parkinson's disease.