Le rôle des lymphocytes B régulateurs chez les patients allergiques au lait de vache recevant l'immunothérapie orale

 

Bahar Torabi

Institut de recherche du Centre universitaire de santé McGill (CUSM)

 

Domaine : Maladies infectieuses et immunitaires

Programme : Formation de maîtrise pour les détenteurs d'un diplôme professionnel

Concours 2016-2017

Partenaire:

Fondation des Étoiles

Regulatory B cells in patients undergoing milk oral immunotherapy.
Cow's milk allergy is a very common problem in children and carries an important nutritional and psychosocial impact. The current treatment is strict avoidance, which can be difficult and accidental ingestion does occur. Our group is undertaking the first Canadian randomized placebo-controlled trial of milk oral immunotherapy at Montreal Children's Hospital and evaluating the clinical and immunological parameters of these children and control subjects. B-lymphocytes are cells specialized for producing antibodies and play a crucial role in the pathogenesis of milk allergy by producing IgE, the primary trigger for cow's milk allergy associated with anaphylaxis. B cells also participate in regulatory and anti-inflammatory activity, such as the ability to tolerate milk proteins; notably as Regulatory B cells. There is increasing interest in defining and harnessing this subset of B cells that produces regulatory cytokines: IL-10 and TGF-β, and inhibitory antibodies: IgA and IgG4.

We hypothesize that milk-allergic children who have successfully completed oral immunotherapy will have a decrease in milk-specific IgE, an increase in milk-specific IgA and IgG4 blocking antibodies, and an increase in milk-specific Regulatory B cells. We will further characterize and distinguish Regulatory B cells: specifically elucidating their characteristic surface molecules and cytokines. This project is part of an ongoing clinical trial with readily available blood samples that will be conducted at the Research Institute of the McGill University Health Centre.

This novel concept can play a pivotal role not only in allergic diseases, but also in inflammatory diseases and autoimmunity.