Identification d'évènements moléculaires et génétiques impliqués dans la genèse des astrocytomes de l'enfant.

 

Nada Jabado

Institut de recherche du Centre universitaire de santé McGill

 

Domaine : Cancer

Program : Chercheurs-boursiers cliniciens - Senior

Concours 2012-2013

Brain tumours including astrocytomas are the most frequent solid neoplasms and the leading cause of cancer-related mortality and morbidity in children. The focus of my research program is to improve our understanding of these deadly cancers and identify relevant therapeutic targets, as little is known about molecular events underlying their development.

We collected a sizeable number of samples from all grade and age astrocytomas, a unique collection from across the world (15 countries), established an international collaborative network and using state of the art tools explored the genome (DNA), epigenome (what protects and regulates our DNA) and transcriptome (messengers from our DNA) of high- and low-grade tumors. Our results identified relevant targets and demonstrated that adult and pediatric tumours are distinct. We identified targets that are driving pediatric astrocytomas and are further investigating their function.

The proposed work will help identify factors rapidly amenable to targeted intervention tailored to the tumor biology, providing novel therapeutic avenues to children that currently have limited options for clinical trials.