Facteurs de risque et impacts de la carence en vitamine D chez les victimes de traumatisme craniocérébral modéré et grave: une étude rétrospective multicentrique

 

François Lauzier

Université Laval

 

Domaine : santé des populations

Programme Consortium pour le développement de la recherche en traumatologie - Volet 2

Concours 2018-2019

Despite the fact that they are younger and have fewer medical comorbidities, victims of moderate and severe traumatic brain injury trauma (TBI) will develop more medical problems than any other patients admitted to the intensive care unit (ICU). These problems include vitamin D deficiency. Several studies suggest that, among the general population, vitamin D deficiency is associated with cognitive decline, depression and dementia. Victims of TBI frequently encounter similar symptoms, but current scientific evidence does not allow to conclude on the true impact of vitamin D deficiency in these patients. Our research project aims to evaluate if, among critically ill patients with TBI, vitamin D deficiency is independently associated with neurological prognosis, functional recovery, quality of life and depressive symptoms. We also aim to evaluate the impact of vitamin D deficiency on hospital length of stay and mortality, and to identify risk factors of developing vitamin D deficiency in the ICU.

To achieve our goals, we will perform a retrospective analysis of the database and the blood sample biobank that we have created over the last years as part of 3 FRQS and CIHR funded research projects. Blood samples from participants recruited in 17 Canadian trauma centres will be analyzed to determine the presence of vitamin D deficiency during their ICU stay and the rehabilitation phase. This project is a crucial and mandatory step before seeking additional research funds to design and conduct a clinical trial that will evaluate the impact of vitamin D supplementation in the ICU on long-term outcomes for TBI patients.