Étude fonctionnelle des récepteurs couplés aux protéines G.

Chercheurs-boursiers -Senior | Concours 2012-2013


Stéphane Laporte

Institut de recherche du Centre universitaire de santé McGill (CUSM)

 

Domaine : Santé circulatoire et respiratoire

G protein coupled receptors (GPCRs) represent one of the major pharmaceutical targets. Action of drugs and hormones on these GPCRs are intricately linked to the constant presence of receptors on the cells surface, which in is regulated by their internalization and intracellular trafficking. Directing the signalling behavior of GPCR can also regulate receptor-mediated responses. We first propose to use innovative molecular and cell biological approaches to identify and study key regulators for the internalization and intracellular trafficking of the angiotensin and bradykinin receptors; two GPCRs involved in cardiovascular and inflammation responses. Moreover, our research has unveiled the properties of a new class of drugs that act in an unconventional way on another GPCR, the FP, to selectively affect the response of the natural hormone. We thus propose to characterize the functional domains of these receptors, known as "allosteric" sites, targeted by our newly discovered compounds, to iteratively generate more selective and efficacious drugs. Our research should have great impact on managing pre-term labour, as well as in the treatment of cardiovascular and inflammatory diseases, and cancer.