Encephalopathie neonatale: comprendre, traiter et ameliorer

 

Pia Wintermark

Institut de recherche du Centre universitaire de santé McGill (CUSM)

 

Domaine : Santé de la mère, des enfants et des adolescents

Programme Chercheurs-boursiers - Junior 2

Concours 2016-2017

 

Some babies are at risk of having brain injury, since they did not receive enough blood supply and oxygen to their brain and other body organs around the time of their birth to keep them healthy (asphyxia). The risk of death or long-term neurological sequelae such as cerebral palsy in these babies is high. Total body cooling is the new standard of care for these babies to prevent the development of brain damage; however, this treatment works well with some babies, but not for others.

My preliminary data suggests that babies who develop brain damages despite cooling already may be identified on day 2 of life while being treated with cooling, and that the available time to influence these brain damages may be longer than initially expected (i.e., a few days/weeks instead of a few hours).

The three goals of this research program are:

1. Understand: To better understand in human term asphyxiated babies treated with hypothermia when brain damage develops despite hypothermia, and how other organ complications related to asphyxia can influence the development of brain damages.

2. Treat: To test innovative treatments to repair the brain damages in a rat model of term neonatal asphyxia.

3. Improve: To test how feasible and safe it would be to administer one of these innovative treatments to human term asphyxiated babies developing brain damage despite hypothermia to improve their outcome.

These data will permit a better understanding of the development of brain damages related to asphyxia and to guide the tailoring of the treatments for these babies, so to decrease their brain injury and thus improve their future neurodevelopmental outcome.