Développement d'une approche innovante pour améliorer la reconstruction de la colonne vertébrale après la résection de tumeurs cancéreuses

 

Michael Weber

Institut de recherche du Centre universitaire de santé McGill

 

Domaine : cancer

Programme chercheurs-boursiers cliniciens - Junior 1

Concours 2015-2016

Bone metastases are the most common cause of cancer-related pain and they often lead to other complications such as bone fractures and compression of the spine, all of which can severely erode patients quality of life. Surgical removal of tumors is one of the main treatments for bone cancers and metastasis. This procedure often leaves a bone defect or ‘hole' that does not heal spontaneously. We have previously developed 3D printed bioceramic bone grafts that can help bone tissue to repair in instances similar to what follows tumor removal.

We propose to further develop these bone implants and to use them as delivery vehicle for the local release of cancer-fighting and bone-regenerating molecules (biphosphanates or BP) at the site of tumor resection. These implants will serve as a reservoir for BP that will slowly release at the bone defect site to improve bone regeneration while also preventing tumor recurrence. Moreover, we aim to develop this bone graft into a modular implant that can be inserted on the spine for fusion by minimally invasive surgery (MIS). The MIS implantation will allow surgeons to precisely target the area of the spine, often invaded by metastatic cells in cancer patient, with minimal disruption of surrounding tissue, resulting in less postoperative pain, faster healing and recovery time to normal pain-free living. One can envision that any relevant drugs could be loaded on these bone grafts, including cancer fighting agents, bone-stimulating bioactives and anti-infectious agents, multiplying the possible applications of this strategy.

From my will to improve complex orthopedic spine surgeries, I envision this proposal to be the cornerstone of a larger program that will deliver innovative and creative orthopedic implants to cancer patients in need.