Développement d'évaluations prédictives à la récupération motrice et locomotrice suite à une lésion traumatique de la moelle épinière

 

Dorothy Barthélemy

CIUSSS du Centre-Sud-de-l'Île-de-Montréal

 

Domaine : neurosciences, santé mentale et toxicomanies

Programme Consortium pour le développement de la recherche en traumatologie - Volet 1

Concours 2018-2019

A traumatic spinal-cord injury (SCI) results in long-term decreased quality of life, and has tremendous social and economical costs associated with the care of these individuals for the remainder of their lives. Hence, it is a priority to develop an efficient therapeutic approach to promote their recovery. Novel rehabilitation protocols tested in recent years, however, have not proven greatly effective in optimizing or accelerating recovery compared to traditional means. One reason for this is that people with such injuries exhibit significant differences in the motor and sensory deficits they experience, and no one treatment can be suitable for everyone. Better assessment of the injury's anatomical and physiological characteristics is needed: A more precise neurological characterization of the lesion will make it possible to identify which neuronal pathway was interrupted by the SCI. As each type of neuronal pathways have a specific function, knowledge of the pathways impaired would indicate the type of deficits most likely to be experienced by the patient.

Furthermore, spared or partially spared neuronal pathways could be trained with new, innovative specific therapeutic approaches to compensate for the severed pathways optimize recovery. If clinicians could have this knowledge early on after the injury, it could guide their interventions and greatly increases the potential recovery. So, in this proposal, we will combine state-of-the-art techniques in electrophysiology and magnetic-resonance imaging to obtain an objective and accurate assessment of deficits after SCI, during the course of 1 year post-lesion. It is expected that the data collected in this study will help identify specific measures which, if used early after the injury occurs, could predict deficits that will develop over time and guide clinicians towards appropriate therapies specifically adapted to each individual with a SCI.