Conséquences rénales à long terme associées à la naissance prématurée : études expérimentale et clinique

 

Adrien Flahault

Centre hospitalier universitaire Sainte Justine

 

Domaine : santé circulatoire et respiratoire

Programme Formation postdoctorale (CITOYENS D'AUTRES PAYS)

Concours 2018-2019

Partenaire :

Fondation des Étoiles

1% of Canadian youth were born extremely preterm (<29 wks; PT). Improvements in neonatal intensive care have resulted in survival of the vast majority of these infants. It has been shown that PT birth was associated with cardiovascular (CV) consequences in the long term, including a higher frequency of hypertension in these patients as well as a higher risk of CV diseases. Adults born PT are also at higher risk of kidney diseases, in part as a result of a lower number of nephrons (the kidney's functional unit) at birth and due to early external kidney aggressions during neonatal care. The cause of the sensitivity of these patients to kidney diseases has not been well determined yet. It is possible that (i) the hyperactivation of the renin-angiotensin system (RAS) and (ii) inflammation, that are both present in PT infants, increase this predisposition to kidney diseases.

Our objective is to determine if there is a link between these two factors and the occurrence of kidney disease in adulthood. For that purpose, we propose a translational research project. The clinical study aims to determine the factors that lead to kidney diseases in young adults born PT, who have had a clinical follow-up during their whole life through a cohort study. In the experimental part of the project, we will study the effects of treatments that modulate the RAS and inflammation in an animal model of prematurity that has been developed in the laboratory. These studies will contribute to a better knowledge of the factors that lead to the occurrence of renal diseases in adults born PT, so that these factors can be avoided, and to evaluate in the animal model the potential impact of drugs that could protect the kidneys of PT infants in the long term.