The human body is composed of trillions of cells that fulfill highly specialized functions in the body, such that acting as a protective barrier against the environment, fighting microbial infections and transmitting nerve signals. In order to carry out these many functions, each type of cell must be able to control its shape with small molecular machines found inside our cells. When these machines have defects, cells may become deformed and this can predispose us to developing different kinds of diseases, such as neuro- and muscle-degenerative disorders and cancer. While most research has focused on the role of protein machines in cellular organization, our laboratory had found that another class of molecules, ribonucleic acids (RNA), also appear to play a major role in this regulation. We use a variety of experimental approaches, including genetic studies of human cells and the fruit fly (Drosophila), as well as bioinformatics approaches, to characterize the roles of RNA molecules in the regulation of cellular morphology These studies will help us better understand the origin of diseases that involve defects in cellular organization.