Approches pharmaceutiques, nutraceutiques et immunologiques pour le traitement des maladies neurodégénératives

 

Frédéric Calon

Université Laval

 

Domaine : Neurosciences, santé mentale et toxicomanies

Chercheurs-boursiers - Senior

Concours 2013-2014

Research projects underway in our laboratory are aimed toward the general objective of developing new therapies for brain diseases, such as Alzheimer's and Parkinson's or essential tremor. To do this, we use different strategies. A first example of approach involves the use of nutraceuticals, such with omega-3 fatty acids. We seek to understand how these natural products can exert beneficial effects in these diseases. Our research team will also work to target cellular cascades involving "p21 activated kinase (PAK)" or to modulate the inflammatory response using intravenous immunoglobulins.

Finally, we are particularly interested in the interface between the brain and the blood, the blood-brain barrier, which prevents many drugs from reaching their target into the brain. To test our scientific hypotheses, our team mainly uses animal models and tissue from people who suffered from these diseases. Our research goals depend mainly on grants hardly obtained in national or international competitions. In summary, the ultimate goal of our work is to accelerate the transfer of knowledge from basic neuroscience to clinical applications for diseases of the central nervous system.