Agitation et délirium en traumatologie et aux soins intensifs


David Williamson

Centre de recherche de l'Hôpital du Sacré-Coeur de Montréal


Domaine : Neurosciences, santé mentale et toxicomanies

Programme chercheurs-boursiers cliniciens - Junior 1

Concours 2016-2017


Consortium pour le développement de la recherche en traumatologie

Traumatic brain injury (TBI) affects more than 15 000 Canadians every year, representing 9% of all hospital admissions for trauma. TBI is the first cause of invalidity and mortality among children and adults between 1 and 44 years. TBI is generally defined as an acute damage to the brain caused by an external force causing a temporary or chronic disability in functional, psychosocial or physical abilities. Psychiatric, cognitive, behavioral and consciousness problems are among the consequences of TBI. During TBI recovery, survivors often develop behavioral and consciousness problems such as agitation and delirium. Intensive care unit (ICU)-acquired has been associated with an increase in length of mechanical ventilation, length of hospital stay, cognitive decline and mortality.

Unfortunately, TBI patients have been systematically excluded form ICU-acquired delirium studies. Difficulties in differentiating delirium from other causes of altered consciousness and the lack of a clear definition for delirium in TBI patients may explain the paucity of research in the subgroup of ICU patients. The objectives of this research program are to describe and understand agitation and delirium, validate instruments for the detection of agitation and delirium, and identify prevention and treatment strategies in TBI patients admitted to the ICU.

The results of this research program will enable the development of effective and safe prevention and treatment strategies including pharmacological and non pharmacological interventions.