Statut psychoaffectif à long terme chez des survivants d'une leucémie lymphoblastique aigue dans l'enfance


Serge Sultan

Centre de recherche du CHU Ste-Justine


Domaine : cancer

Programme recherches sur le cancer

Concours 2014-2015



Ministère de la Santé et des Services sociaux

Long-term follow-up of Acute Lymphoblastic Leukemia (ALL) survivors has become a major preoccupation. Although we know some long-term effects of anti-cancer therapies (e.g. cardiac or neurologic effects), we still have few data on long-term emotional effects. The objectives of this project are: to describe emotional issues in this population, to test a simple tool to detect these issues, to identify neurologic and cognitive causes of emotional distress, to estimate the impact of treatments on emotional issues, and isolate the role of age on this description and the experience of distress.

To reach these goals, we will interview all Canadian patients who were treated with a Dana Farber Cancer Institute (DFCI) protocol from centres in Montreal, Quebec and Hamilton (N=400 approximately). During a routine examination, participants will be proposed a standardized psychological assessment (cognitive and affective aspects). These data will be linked with a precise description of treatment history available from the medical files. In a sub-sample in Montreal, neuroimaging is also available. Advanced statistical methods will be used to estimate the size of association between emotional distress measures and neurocognitive deficits, neurologic suffering and treatment itself.

This project will provide a detailed description of affective issues in a very homogeneous population, both clinically and treatment-wise. It will identify cognitive causes for these difficulties and provide validation data for a simple and easy-to-use case-identification strategy in order to improve distress recognition in the follow-up clinics. It will identify risk-factors of emotional issues among treatment history and thus will provide new criteria to assess the effects of treatments.