L'impact des hormones sexuelles et la fonction neurovasculaire sur la sante cardiovasculaire des femmes


Charlotte Usselman

Université McGill


Domaine : santé circulatoire et respiratoire

Programme Chercheurs-boursiers - Junior 1

Concours 2019-2020


Fondation des maladies du cœur et de l'AVC du Québec

The body's nerves and blood vessels each play important roles in determining the function and health of the cardiovascular system. Studies conducted in non-human species have shown that these systems are both under the control of estrogen, progesterone, and/or testosterone (i.e. sex hormones). Interestingly, data regarding cardiovascular disease rates in humans show that people who experience changes in their body's sex hormones are likely to experience a change in their level of cardiovascular disease risk. Together, these findings support the idea that sex hormones play an important role in controlling the body's nerves, blood vessels, and determining overall cardiovascular health.

However, very little research has examined the interactions between sex hormones and the nerves and blood vessels in humans. Critically, this gap in knowledge has limited our ability to prevent and treat cardiovascular disease in certain populations, and particularly in women. Therefore, the goal of this research program is to explore the complex interactions between circulating sex hormones and the nerves and blood vessels of the body as they determine cardiovascular function and health in women. This line of questioning is designed to test the central hypothesis that sex hormones (including estrogen, progesterone, and testosterone) directly modulate the function of the nerves and blood vessels such that changes to the hormonal milieu result in clinically meaningful effects on cardiovascular function and health.