Le trouble dépressif majeur et le comportement suicidaire: facteurs neurobiologiques et cliniques

Chercheurs nationaux | Concours 2012-2013

Gustavo Turecki

Centre de recherche de l'Hôpital Douglas


Domaine : Neurosciences, santé mentale et toxicomanies

The most severe complication of major depressive disorder is suicide completion. On the other hand, the majority of patients with major depressive disorder will not die by suicide. Why some patients commit suicide while others do not is a question that has long been puzzling both researchers and clinicians and is the focus of the proposed research program. The objectives of the proposed program are to continue with a line of work centered on the investigation of clinical and biomedical risk factors for suicide. Specifically over the period of the proposed research program, my aims are the following, 

1) To better define clinical and behavioral risk factors for suicidal behavior in patients with major depressive disorder. 

2) To study neurobiological factors underlying the suicidal behavior in major depressive disorder, with a special emphasis on the polyamine system. 

3) To investigate the role of epigenetic factors in major depression and suicide.