Vieillissement et cognition dans la sclérose en plaques : rôle de la réserve cognitive


Alexandra Tremblay

Centre de recherche du Centre hospitalier de l'Université de Montréal


Domaine : vieillissement

Programme Formation de doctorat

Concours 2018-2019

Partenaire :

Société canadienne de la sclérose en plaques

Multiple sclerosis (MS) is a chronic disease that affects the central nervous system and, in more than half of cases, the cognitive functioning of patients. With the currently available treatment, patients' life expectancy has been greatly improved over the past two decades. In addition, recent studies point out that there are more and more people who develop the disease after age 60. To date, very few studies have focused on the effects of aging in MS, let alone the evolution of cognitive impairment in aging patients. However, the synergistic relationship between disease and normal aging processes may soon become a new obstacle for clinicians and patients. As patients grow older, comorbidities and physiological changes related to normal aging may amplify the severity of disabilities and deficits.

We therefore propose to study cognitive impairment in MS in relation to aging in order to differentiate the effects of age and disease duration. More particularly, we aim to distinguish cognitive impairment directly related to MS from the one associated with normal aging processes or age-related pathology (e.g., Alzheimer's disease). The protective role of lifestyle, education and engagement in cognitively challenging activities (e.g., reading) factors will also be considered in relation to cognitive functioning. This is intended to identify predictors of healthy cognitive aging in MS.