Utilisation du charbon activé chez les patients intoxiqués (CHARPP - Use of activated CHARcoal in Poisoned Patients)

 

Maude St-Onge

Centre de recherche du CHU de Québec - Hôpital de l'Enfant-Jésus

 

Domaine : Services de santé

Programme chercheurs-boursiers cliniciens - Junior 1

Concours 2016-2017

PROBLEM: Poisonings represent an important social burden. In 2010 poisonings were responsible for 24,024 hospitalizations and 5,516 deaths. In addition, toxicology involves vulnerable populations such as children with involuntary ingestions or patients attempting suicide. Unfortunately, the current practice in toxicology is not based on solid data, which is an important issue for the use of activated charcoal, one of the most frequently used interventions.

OBJECTIVES: The aim of this research program is to describe the benefits and risks associated with the use of activated charcoal in poisoned patients, and to target appropriate indications.

METHODS: The research program aims to describe the current state of knowledge, current practices and opinions with a systematic review, a retrospective study and a survey of key stakeholders. These studies will be followed by a clinical trial evaluating prospectively the use of activated charcoal.

  • The systematic review documents if the use of activated charcoal in poisoned patients reduces mortality, length of stay and toxicity. Il will also document side effects.
  • The retrospective study describes the number of poisonings and the characteristics of patients receiving or not activated charcoal. It will also compare the outcomes and side effects.
  • The survey of Canadian key stakeholders will notably explore their opinions in regard to the indications and contrindications of activated charcoal.
  • The latest study will evaluate the feasibility of a clinical trial comparing a group of patients receiving activated charcoal compared to a similar group not receiving the intervention.

IMPACT: The results of this research program will inform future health policies and will contribute to develop recommendations guiding clinicians practices.