Utilisation de la génétique pour comprendre la biologie du vieillissement et de la pathogenèse des maladies neurodégénératives

 

Jeremy Van Raamsdonk

Institut de recherche du Centre universitaire de santé McGill

 

Domaine : vieillissement

Programme Chercheurs-boursiers - Junior 2

Concours 2018-2019

As the population of Quebec and Canada ages, there is an increasingly urgent need to understand the aging process and its role in age-onset disorders, such as Alzheimer's and Parkinson's disease. Currently, there are almost 6 million Canadians over the age of 65, which is more than 15% of the total population. In addition to the general decline in health that occurs with age, aging is the greatest risk factor for the development of neurodegenerative disease. Nonetheless, the role of aging in these diseases remains undefined, and the aging process is poorly understood.

By advancing our understanding of the aging process, we believe that the knowledge obtained may not only be used to promote healthy aging but also to treat neurodegenerative disease. The primary objectives of this work are: (1) To determine the molecular mechanisms underlying the aging process; and (2) To define the role of aging in Parkinson's disease. Overall, this research will advance our understanding of the aging process and mechanisms involved in Parkinson's disease. This work may lead to novel treatments that promote healthy aging and reduce the severity of age-onset neurodegenerative disease.

Accordingly, this research has the potential to improve the quality of life of older individuals and to decrease health care spending in Quebec and throughout Canada.