Traitement pharmacologique et comportemental des pathologies de la perception auditive : Approche translationnelle de l'animal à l'homme

Chercheurs-boursiers- Junior 2 | Concours 2012-2013

Matthieu Guitton

Centre de recherche Université Laval Robert-Giffard (CRULRG)


Domaine : Neurosciences, santé mentale et toxicomanies

Due to the aging of the population and to the increase of noise pollution, pathologies of auditory perception (particularly tinnitus ringing in the ear, and presbyscysis age-related hearing loss) are nowadays a major problem of public health. My research program aims, in a translational logic integrating research in animals and in humans, to combine pharmacological and behavioural approach to develop new therapeutic solutions to cure the pathologies of auditory perception. This program is organized into three main axes. The two first axes (the first axe on tinnitus, the second axe on presbycusis) are dedicated to the study of biological mechanism of pathologies of auditory perception with the utilisation of innovative animal models to develop new pharmacological solutions to treat sufferers. The third axe aims to increase our knowledge on the immersive process in virtual spaces in order to develop new virtual reality tools to optimize behavioral therapies for patients refractory to the pharmacological treatments. By combining various and innovative approaches, our research program will lead to an increase of our knowledge on the multi-modal and pathological aspects of auditory perception. Our project will greatly contribute to the development of new combined (pharmacological and behavioural) therapeutic strategies to cure the patients suffering from tinnitus and presbycusis. Thus, our program will clearly contribute to increase the health and quality of life of Quebec and Canadian population.