Rôles de la synthèse protéique et du métabolisme énergétique dans le cancer

 

Ivan Topisirovic

Institut Lady Davis de recherches médicales de l'Hôpital général juif

 

Domaine :   cancer

Programme chercheurs-boursiers - Junior 2

Concours 2017-2018

Energy metabolism is the process which cells use to convert nutrients into energy. In addition to providing cells with energy, metabolites that are by-products of energy metabolism are ultimately used by cells to support their growth. Translation of the messenger RNAs (mRNAs) is a process during which translational apparatus decodes information stored in the mRNA to produce proteins. mRNA translation machinery consumes large proportion of cellular energy. Nonetheless, how mRNA translation and energy metabolism communicate with each other remained largely elusive. With the help from FRQ-S, we carried out studies to address this important gap in knowledge and found that the signaling pathways called mammalian/mechanistic target of rapamycin complex 1 (mTORC1) stimulates energy production by increasing translation of mRNAs that encode components of cellular complexes that generate energy.  

Malignant transformation, which is a process during which normal cells become cancerous, is characterized by dramatic changes in both energy metabolism and mRNA translation.  Herein, we propose to carry out studies aiming to identify changes in mRNA translation and energy metabolism that distinguish cancer cells for their normal counterparts. We trust that identifying these features of cancer cells will highlight their vulnerabilities. We therefore hope that in long-term our findings will contribute to the efforts to target translational machinery and energy metabolism in cancer without causing major damage to normal tissues.