Rôle de Nlrs en neuroinflammation et de la neurodégénérescence

Chercheurs boursiers - Junior 1 | Concours 2012-2013

Denis Gris

Université de Sherbrooke


Domaine : Neurosciences, santé mentale et toxicomanies

The goal of my career as an independent investigator is to make fundamental contributions to advance knowledge in neurodegenerative and neuroinflammatory diseases. To reach this goal, I have planned a research program to discover novel mechanisms that control inflammatory processes within the central nervous system Multiple sclerosis (MS) affects people of 25 to 40 years. Canada has one of the highest rates of MS incidence in the world (1/25,000). Inflammation is the key target to develop therapies to treat MS. Multiple studies demonstrated that novel family of proteins called nod-like receptors (Nlrs) are among the main regulatory proteins of the immune response.
The goal of this program is to study the role of Nlrs in MS. In the first 4 years, I will study the role of Nlrx1 and Nlrp12 in MS. Our preliminary data suggest that these proteins may become a target for novel therapeutic intervention as they both suppress inflammation during progression of MS
These novel and fundamental observations form the basis of my program to investigate the role that Nlrx1 and Nlrp12 in the pathology of MS. I have constructed three independent projects to mechanistically dissect contribution of these genes to MS pathology.
This program is designed to increase understanding of regulatory processes of neuroinflammation in MS. The lessons learned during these 4 years will be applied to study contribution of NLrs to other neurodegenerative diseases including Parkinson¿s disease and Alzheimer¿s disease. The function of Nlrs is an emerging field of study which, so far, has been approached by studying the response of the immune system against pathogens. Uncovering the role of Nlrs in neuroinflammation opens a potential to find novel therapeutic approaches to treat neurodegenerative diseases