Réservoirs du VIH et stratégies d'éradication

 

Numa Dancause

Université de Montréal

 

Domaine : neurosciences, santé mentale et toxicomanies

Programme Chercheurs-boursiers - Senior

Concours 2018-2019

After stroke, many people have persistent impairments that interfere with activities of daily living. A particularly debilitating symptom is the reduced ability to use the hand. It is well known that some recovery occurs in the weeks following injury, but that recovery is often incomplete. More effective therapies are urgently needed to promote the return of function after stroke. To improve treatments, we need a better understanding of how the normal brain controls movements and the changes that allow the injured brain to recover some movements. With this knowledge, we will be able to propose new approaches that can maximize the positive changes and improve the recovery of hand movements.

The general objective of my research is to understand the mechanisms involved in the control of hand movements and the changes that support movement recovery after stroke. We are particularly interested in regions of the brain called ‘premotor areas'. Several studies, including my own work, have shown that these areas undergo large-scale reorganization after stroke. Our general hypothesis is that premotor areas play major roles in the control and recovery of hand movements after stroke.

We conduct several projects in which we study 1) the way premotor areas participate in the control of hand movements; 2) the reorganization and the role premotor areas play in spontaneous recovery (i.e. without treatment) after stroke; 3) the effects of novel treatments that shape the activity in premotor areas to increase post-stroke recovery. We take great care to align our projects to studies conducted in humans and stroke patients. This helps to transfer our findings to design new treatments that will be tested by our collaborators in clinical trials. This systematic approach will lead to the development of more effective treatments and, ultimately, a better quality of living for stroke patients.