At its core, cancer is a problem of uncontrolled cell proliferation, which is the result of aberrant cell growth and division. Protein synthesis is essential for cell growth, and its dysregulation is a frequent feature of cancer. For this reason, components of the protein synthesis machinery represent potential therapeutic targets for novel anticancer drugs.
Our lab is focused on defining how protein synthesis is deregulated in cancer cells, as this knowledge is crucial for the discovery of improved disease biomarkers, the identification of novel therapeutic targets, and to decipher the molecular causes of therapeutic resistance. We have a long-standing interest in the study of protein synthesis, and our expertise places us in a privileged position to make important contributions in the field of cancer research.