Régulation de la fonction des cellules T CD8 par les cytokines

 

Martin Richer

Université McGill

 

Domaine : Maladies infectieuses et immunitaires

Programme chercheurs-boursiers - Junior 1

Concours 2016-2017

CD8 T cells are immune cells that play an important role in protecting the host from infections. While these cells are usually protective, they can also cause disease if they are not properly regulated. We are interested in studying the impact of environmental cues on the optimal function of CD8 T cells. Our previous results have demonstrated that a particular subset of environmental cues produced following infection, plays an important role in regulating CD8 T cell function. We will focus our studies on how these environmental cues act to alter the biology of CD8 T cells following infection.

The information generated from our work will increase our understanding of how the immune system is regulated. In addition, the data generated in our studies are likely to yield important information that may allow us to develop new therapeutic targets. These therapeutic targets would aim to reduce the function of CD8 T cells in a situation where they cause disease (e.g. autoimmunity or transplant rejection) and increase their function in a situation where they do not function adequately (e.g. chronic infection or cancer). In addition, our research is likely to lead to the identification of novel CD8 T cell based vaccination approaches.