Recherches sur la dégénérescence maculaire liée à l'âge (Programme DMLA)

 

Elvire Vaucher

Université de Montréal

 

Domaine :   vieillissement

Programme recherches sur la dégénérescence maculaire liée à l'âge (Programme DMLA)

Concours 2017-2018

Age-related macular degeneration (AMD) is the leading cause of legal blindness in older people in industrialized countries. This disease is characterized by an alteration of the retina and vision due to the proliferation of aberrant blood vessels. This neovascularization is induced by the disruption of growth factors (notably VEGF, vascular growth factor) and inflammation. The current therapy targets VEGF, but has many limitations including relative efficacy, frequency and discomfort of treatment. Given the involvement of kinins in retinal inflammation and the pathological events that may lead to neovascularization, we want to evaluate their impact in a model of AMD, choroidal neovascularization (CNV) and an in vitro model on engineering reconstructed tissues that model neovascularization. The purpose of this study is twofold: (1) to evaluate the impact of kinin receptor inhibitors on inflammation and choroidal neovascularization, and (2) the interaction of kinins with VEGF.

This project will therefore improve the effectiveness of current treatments and develop a new approach to treat AMD: the use of kinin B1R receptor inhibitors, already targeted to prevent macular edema in retinopathies. The impact can be very rapid since the pharmacological compounds are already approved by the FDA and Health Canada. This project will also make it possible to exploit a model of analysis of the mechanisms of neovascularization in vitro. Given the lack of in vivo models of neovascularization in the retina, this in vitro model is very interesting for the development of new drugs.