Recherches observationnelles portant sur les maladies systemiques autoimmunes rhumatismales

Chercheurs-boursiers cliniciens- Junior 2 | Concours 2012-2013

Marie Hudson

Institut Lady Davis de recherches médicales de l'Hôpital général juif


Domaine : Maladies infectieuses et immunitaires

My main focus of research is scleroderma. This is a rare, disfiguring disease that causes fibrosis of the skin, the lungs and other internal organs. I am interested in studying whether drugs that suppress the immune system are useful to treat and prevent the lung disease in scleroderma. Another rare complication of scleroderma is scleroderma renal crisis. It is associated with a high risk of dialysis and death. I am trying to understand whether scleroderma patients who use drugs called ACE inhibitors have a worse prognosis if they develop scleroderma renal crisis. Finally, I am part of an international network of researchers and patient representatives dedicated to developing interventions to improve the quality of life of scleroderma patients.
I also study inflammatory myositis. This disease affects muscles and causes severe pain and weakness. I am in the process of developing a database to collect data on patients with this disease. This will help us better understand how these patients evolve over time. 
I am a member of the Canadian Network for Improved Outcomes in Systemic Lupus Erythematosus. We pursue research in the field of systematic lupus erythematosus with the ultimate goal of improving the lives of patients with this rare but serious disease.
Finally, I pursue cross-disease research in scleroderma, inflammatory myositis and systemic lupus erythematosus. I believe that studying the commonalities, and differences, between these related diseases may serve to make new discoveries about their causes and outcomes.
My work has the potential to directly impact the care of patients with systemic auto-immune diseases. In addition, the methodology that I use is cutting-edge and has the potential to inform the research community on how to study rare diseases.