Progression de la Maladie au niveau du Ventricule Gauche, de la Valve Aortique et de l'Aorte chez les Patients avec une Bicuspidie Valvulaire Aortique


Mylène Shen

Institut universitaire de cardiologie et de pneumologie de Québec


Domaine : santé circulatoire et respiratoire

Programme Formation de doctorat

Concours 2018-2019

Partenaire :

Fondation des maladies du cœur et de l'AVC du Québec

Bicuspid aortic valve (BAV) is the most frequent congenital heart disease in the population (1-2%). The aortic valve, which role is to ensure an optimal unidirectional circulation of the oxygenated blood flow from the left ventricle (LV) to the aorta, is normally composed of 3 valvular leaflets. However, in BAV patients, the aortic valve is only composed of 2 valvular leaflets. Thus, BAV patients are more at risk of developing complications and dysfunctions that can affect directly the aortic valve (ex: aortic stenosis, aortic insufficiency) but also the aorta (ex: aortic dilatation) and the LV (ex: LV dysfunction, LV hypertrophy, LV dilatation). However, the presentation and the evolution of these patients are very variable and heterogeneous which is a real challenge in the management of the patients.

The research project has the objectives of investigating the mechanisms implicated in the alteration of the LV, the aortic valve and the aorta in patients with a BAV and understanding how these different components interact between themselves. Then, we will be able to better understand the physiopathology, the evolution and the progression of the LV, the aortic valve and the aorta in patients with a BAV and to have progression determinants more adapted and/or specific to the BAV patients. In the long term, it will improve the risk stratification of those patients and their management as they are generally patients that are more at risk.