Programme de recherche évaluative en chirurgie cardiaque adulte

 

Louis-Mathieu Stevens

Centre de recherche du Centre hospitalier de l'Université de Montréal

 

Domaine : santé circulatoire et respiratoire

Programme chercheurs-boursiers cliniciens - Junior 2

Concours 2015-2016

I am a clinician-scientist, associate professor, active cardiac surgeon and I hold a PhD in biomedical sciences (applied biostatistics). My dynamic program includes three major modules.

My first module is my trial AMI-PONT (objective: 200 patients, randomly distributed), funded by the Canadian Institutes of Health Research. Cardiac bypass grafting (CABG) surgery is an efficient way to provide blood to the vessels supplying the heart when these vessels are diseased. The best CABG conduit, or graft, is an artery found behind the breastbone (LIMA) which we usually connect to a vessel in front of the heart. We developed a practical technique to expand the reach of the LIMA to more than one vessel using a short venous graft. Preliminary data with this technique are promising with several added benefits. Namely, the technique is relatively easier to perform and shorter venous grafts are required. With AMI-PONT, I'm assessing whether the graft patency with this strategy are not inferior, or not worse, compared to a conventional strategy. My patients will be followed for ten years, and will undergo at one year a scan using X-rays to safely, quickly and precisely evaluate graft patency.

My second module involves my studies derived from the large international clinical trial CORONARY comparing CABG surgery with or without the use of the heart-lung machine, and includes our clinical trial PATENCY-CORONARY assessing CABG graft patency among CORONARY patients.

My third module is studying the impact older age in cardiac surgery.  This is the first multicentric study using the Quebecer clinical registry in cardiac surgery where I play a major role as a surgeon with a unique expertise in epidemiology and biostatistics. I am also involved with several research groups.
 
Overall, my research program and its original projects truly target critical unanswered questions in the cardiovascular field.