Programme de recherche en paralysie cérébrale: causes et conséquences

 

Maryam Oskoui

Institut de recherche du Centre universitaire de santé McGill

 

Domaine :  santé de la mère, des enfants et des adolescents

Programme chercheurs-boursiers-cliniciens  - Junior 2

Concours 2017-2018

Cerebral palsy (CP) is the most common cause of physical handicap in children, with many other associated difficulties. My overall goal is to reduce the burden of CP.

  1.  Portrait of children with CP in Canada: I will use the Canadian Cerebral Palsy Registry (CCPR) to describe the profile of children with CP across Canada, and see what factors affect outcomes. This information will help inform health policy.
  2. Identify patterns in health services use: Administrative health databases (AHD) record information on doctors' visits and hospital stays for large numbers of people over time. We do not know how well they can identify children with CP. I will link the CCPR with AHD to find a reliable way of identifying children with CP in AHD and describe how they use health services.
  3. The role of genetics in CP: To better understand how our genetic makeup can cause different forms of CP, we will invite children and their parents from the Canadian CP Registry (CCPR) to give a blood sample. From their blood, we will read all of their genetic information. With a better understanding of the genetic causes of CP, doctors will be able to diagnose CP earlier, and provide therapy specific for each person.
  4. Identify risk factors for Neonatal Encephalopathy (NE): NE is a serious neurological complication that occurs during the first few days of a baby's life, putting them at high risk for CP. To better understand the causes of NE, we will compare placentas of babies with and without NE to see if there are any differences. More information on the causes will help prevent NE, develop new treatments and improve counselling.