Optimisation de la gestion de la douleur péri-opératoire chez les enfants ayant des pathologies musculosquelettiques


Catherine Ferland

Université McGill


Domaine : santé de la mère, des enfants et des adolescents

Programme Chercheurs-boursiers - Junior 1

Concours 2018-2019

Musculoskeletal pain is one of the most common types of pediatric pain. The pain may result from a pathological condition or corrective surgery. In Canada, approximately 65,000 children undergo surgery each year and are at risk of developing chronic postsurgical pain (CPSP). If the pain is handled inappropriately by the young patient, it may result in adverse effects which will continue throughout adulthood. It is of great importance to improve the clinical evaluation of pain in order to minimize its intensity and to understand why some patients respond better than others to certain pharmacological treatments. 

This research program aims to personify the treatment of pain by identifying the sensory and physiological differences in the pain patient profile. We will evaluate clinically the dynamic mechanisms of pain transmission using sensory tests, while performing in parallel a biochemical assessment of the excitatory and inhibitory pain processes to identify biomarkers of the pain experience. These biomarkers will help better target pharmacological treatments specific to potentially impaired pain processes. We will explore the association between these objective assessments of pain and the patient's perception. This evaluation will be conducted in patients who report chronic back pain, in patients who undergo a spine surgery and in patients who are followed for the CPSP. Research will be conducted at the Shriners Hospital for Children-Canada.