Nouveaux outils non-invasifs pour la détection précoce de la pathologie de la maladie d'Alzheimer


Claudio Cuello

Université McGill


Domaine : Neurosciences, santé mentale et toxicomanies

Fonds d'onnovation Pfizer-FRQS

Concours 2013-2014

By the time an Alzheimer's disease (AD) diagnosis is made, the brain has suffered extensive and irreparable damage such that new, effective therapies are hard to find. It is becoming clear that the disease starts decades prior to clinical diagnosis. Diagnostic tools to reveal this ''silent'' pre-diagnostic stage of AD are not yet available. There is indication that a neuronal/metabolic dysfunction occurs in such silent stage as well as a toxic pro-inflammatory process. The main goal of this multidisciplinary research is to address this unmet medical need by developing novel platforms to image the brain, revealing the onset and progression of neuronal/metabolic and inflammatory events on a suitable (and novel) animal modelling the silent stages  of AD.  The investigations are of potential translational significance for the early diagnosis and early treatment of AD.