Nouveaux joueurs qui façonnent la cellule T: d'ions aux lipides

 

Étienne Gagnon

Université de Montréal

 

Domaine : maladies infectieuses et immunitaires

Programme chercheurs-boursiers - Junior 2

Concours 2017-2018

The immune system empowers humans to ward off infections and to protect against the emergence of cancers. The T cell is at the heart of this system and orchestrates the immune response against external invaders, such as bacteria and viruses, as well as internal, such as cancer cells. In order to develop optimized clinical approaches in order to treat sick patients, it is imperative that we understand the molecular mechanisms that regulate of T cell activation. With the use of unique and innovative experimental approaches, we have put forth a research program that drives the discovery of novel mechanisms governing T cell activation in a protective immune response.

Our research also dives into the understanding of how cancers subvert the immune response by inducing immune tolerance, thereby preventing an anti-cancer immune response. Though our research is mainly focused understanding the fundamental aspects of the immune response, findings made by our research set a strong foundation to develop novel approaches or improve current immunotherapeutic anti-cancer approaches in order to improve patient outcome