Nouveaux Effecteurs Moléculaires de la Barrière Hémo-Encéphalique Impliqués dans la Sclérose en Plaques

Chercheurs-boursiers - Senior | Concours 2012-2013

Alexandre Prat

Centre de recherche du CHUM


Domaine : Neurosciences, santé mentale et toxicomanies

The Blood-brain barrier (BBB) is an important structure that protects the brain by restricting the passage of cells and of molecules from the blood to the brain and spinal cord. In several diseases of the brain, including the disease multiple sclerosis (MS), the BBB fails to prevent the migration of aggressive white blood cells (called leukocytes) into the brain. These leukocytes are known to be the effectors involved in damage to brain cells. Our work focuses on both the intact and damaged BBB and its role in the development of inflammatory diseases directed to the brain. The current proposal intend to understand the molecular mechanisms which govern the migration of specialized subset of white blood cell across the BBB and to study the specific role of a new adhesion molecules in the recruitment of these cells to the brain. Current data from our lab provide the basis supporting that new pharmacological therapies directed against these molecules reduce brain inflammation and the symptoms of MS in the animal model of the disease.