Métabolisme bioénergétique et réponse fonctionnelle des cellules inflammatoires : Étude de facteurs endogènes et environnementaux

 

Martin Pelletier

Université Laval

 

Domaine : appareil locomoteur et arthrite

Programme Chercheurs-boursiers - Junior 2

Concours 2018-2019

Aberrant inflammatory responses contribute to the development and progression of chronic diseases, like gout, rheumatoid arthritis, colitis and auto-inflammatory diseases. While treatments greatly improved over the years, optimal therapy is frequently delayed by improper patient stratification. To improve patient care and develop new therapeutic strategies, my research program focuses on identifying the molecular mechanisms underlying inflammation and determining the roles of intrinsic and extrinsic factors involved in triggering, maintaining and resolving inflammation in chronic diseases.

My laboratory specifically investigates environmental and host factors that modulate energy metabolism and the functional responses of inflammatory cells. At first, we characterize the effects of endocrine disruptors on inflammatory cells' bioenergetics to identify unexpected adverse effects of these chemicals and explain how they contribute to inflammation. Secondly, we characterize the bioenergetic events involved in inflammatory cells' aberrant activation in gout, rheumatoid arthritis and colitis. Finally, we characterize the white blood cells' inflammatory molecule production profile of auto-inflammatory patients to accelerate diagnosis and selection of the best treatment for each patient of these rare diseases.

This work will lead to a better understanding of the mechanisms leading to the inappropriate activation of inflammatory cells and allow a mechanism-based approach to evaluate the efficacy of current treatments, with the expectation to develop improved biomarkers and new therapeutic tools, bringing the field one step closer to personalized medicine.