Mécanismes de signalisation intracellulaire régulant l'inflammation suite aux infections pulmonaires

Chercheurs-boursiers-Junior 2 | Concours 2012-2013


Simon Rousseau

Centre universitaire de santé McGill (CUSM)

 

Domaine :Santé circulatoire et respiratoire

When inflammation in the lung is deregulated, respiratory disorders will occur, leading to significant losses in quality of life. If the inflammatory response is loss, there is increased susceptibility to respiratory infections. On the other hand, in the presence of excess or chronic inflammation, lung tissue will be damage, which can lead to respiratory failure and death. My research program aims at understanding the intracellular signals regulating inflammation in response to bacterial infections, in order to devise novel strategy to re-establish a balanced inflammatory response when it goes awry. For the next four years I plan to study: (A) the mechanisms regulating inflammation in the healthy airway epithelium upon bacterial infection; (B) the mechanisms responsible for chronic inflammation in Cystic Fibrosis; (C) and the mechanisms responsible for the increased sensitivity to infections in the lungs of children suffering from Niemann-Pick disease. Objectives B and C are centered upon very serious diseases that have a major impact on respiratory health. At the core of these three projects is the central role played by intracellular signalling pathways regulating inflammation. This research program starts by investigating clinical samples, before studying the mechanisms regulating inflammation in human cell culture model to finally validate our discoveries in vivo, using a murine lung infection model. I believe that these approaches combined are essential to have effective knowledge transfer from the clinic to the bench, and then back to the clinic, in order improve the quality of life of Quebecers suffering from pulmonary infections.