Les infections chroniques du Pseudomonas aeruginosa: de la microbiologie a la reponse inflammatoire des voies respiratoires

 

Dao Nguyen

Institut de recherche du Centre universitaire de santé McGill

 

Domaine : maladies infectieuses et immunitaires

Programme Chercheurs-boursiers cliniciens - Senior

Concours 2018-2019

My research program entitled "Les infections chroniques du Pseudomonas aeruginosa: de la microbiologie a la reponse inflammatoire des voies respiratoires" is focused on respiratory infections caused by the bacterium Pseudomonas aeruginosa. This bacteria causes devastating chronic infections in patients with the genetic disease cystic fibrosis. Although these infections may be cleared with the help of antibiotics at the beginning, they often become chronic and nearly impossible to clear thereafter.

Our studies focus on the interactions between the bacteria and host responses. Our goal is to find ways to improve clearance of Pseudomonas when infection first starts, and to understand how Pseudomonas causes lung disease in cystic fibrosis patients by altering the immune and inflammatory responses of the host.