Les infections chroniques du Pseudomonas aeruginosa : de la microbiologie à la réponse inflammatoire des voies respiratoires

 

Dao Nguyen

Institut de recherche du Centre universitaire de santé McGill

 

Domaine : maladies infectieuses et immunitaires

Programme chercheurs-boursiers cliniciens - Junior 2

Concours 2015-2016

My research program entitled "Les infections chroniques du Pseudomonas aeruginosa : de la microbiologie à la réponse inflammatoire des voies respiratoires" is focused on respiratory infections caused by the bacterium Pseudomonas aeruginosa. This bacteria causes devastating chronic infections in patients with the genetic disease cystic fibrosis that are nearly impossible to clear with antibiotics. Our studies focus both on the bacteria as well as the host responses they trigger. On the microbe side of research, our goal is to understanding why bacteria are often "indifferent" to antibiotics and survive even harsh treatments. This drug indifference is termed tolerance and makes antibiotics much less effective than they should be. We want to determine how bacteria protect themselves against antibiotic killing through some stress responses, and whether antibiotic kill bacteria by causing oxidative stress.

Our long-term goal is to help the development of new and more effective therapies against chronic Pseudomonas infections. On the host side of research, we are interested in understanding how the bacteria Pseudomonas affects the lung and alters the inflammatory responses triggered by this infection. During a chronic infection, the infecting bacteria has the chance to evolve and change a lot. Our studies are therefore aimed at defining how the evolution of the bacteria will affect the inflammatory responses in the lung, and how this contributes to the gradual worsening of lung disease in cystic fibrosis patients.