Le rôle des rythmes circadiens dans la douleur et la sclérose en plaques

 

Julia Segal

Queen's University

 

Domaine : neurosciences, santé mentale et toxicomanies

Programme Formation de doctorat

Concours 2019-2020

Partenaire:

Société canadienne de la sclérose en plaques

Half of all people living with multiple sclerosis (MS) suffer from pain, with few viable options for treating this aspect of the disease. Recent evidence from our lab and others has identified a circadian (24 hour) rhythm to both chronic pain and neuro-immune responses. Whether circadian rhythms also control disease progression, pain, and pathophysiology in MS remains unknown. We propose to use molecular, cellular and behavioural techniques to identify whether MS-related pain and symptoms have a circadian rhythm and whether the progression of the disease can be affected by altering the circadian system. We will use an animal model of MS to assess whether this "internal clock" controls clinical symptoms of disease, including pain and tissue damage.

Our hypothesis is that the circadian system controls novel molecular and cellular mechanisms underlying disease. Better understanding these interactions may ultimately lead to the identification of novel therapeutic targets for the treatment of MS and guide physicians to take advantage of the body's natural rhythms in an effort to improve patient care.