Le rôle des interactions entre la protéine HuR et ses partenaires protéiques dans le cancer

 

Christopher von Roretz

Collège John Abbott

 

Domaine : cancer

Programme d'appui à la recherche pour les enseignants-chercheurs de collège

Concours 2015-2016

Cancer is the result of a failure in the regulation of routine cellular events. One example of this is the ability for a cell to die when it is exposed to external stresses, or failure to respond to its normal signals. Cancer cells block this normal cell-suicide mechanism, called "apoptosis", and as a result can grow uncontrollably. Studying the process of apoptosis, and how cancers block it, has been a major area of research in combating cancer. I was previously involved in the discovery of a particular factor that is implicated in cell death. The protein HuR has a variety of methods by which it influences many different cellular processes, including cell growth, of which there is an abundance in cancer, and apoptotic cell death, which is lacking in cancerous tissue.  This dichotic role of HuR makes it an interesting candidate for further research, to try and understand how this one protein can interact with factors that both promote and inhibit cancer development. In my previous work, we found that HuR coordinates both cell survival and cell death by being modified in response to lethal stress. This modification in HuR influences its behaviour and enhances cell death.

In this proposal, I outline how I wish to better understand what interactions HuR has with other proteins, before and after it is modified, and the importance of these interactions in the role HuR plays in apoptosis. Advancing our knowledge of how this crucial protein player works in this process has the potential to identify novel therapeutic targets for treatment of cancer.