Le rôle de la nutrition et de l'inflammation dans la prévention et le traitement du cancer de la prostate

 

Vincent Fradet

Centre de recherche du Centre hospitalier affilié universitaire de Québec

 

Domaine : cancer

Programme chercheurs-boursiers cliniciens - Junior 2

Concours 2014-2015

Prostate cancer (PCa) is a major public health issue. It is the number one cancer diagnosed in men. Studies done in Inuit men who traditionally eat a lot of fatty fish (such as salmon) have suggested that omega-3 (contained in these fish) can help prevent PCa. Other studies have suggested that omega-3 could work by decreasing the inflammatory response, which is deregulated in cancer.

My career objective is to study how omega-3 can act on the inflammatory response in the context of PCa. I have already recruited 120 patients in my first clinical evaluating the molecular effects on prostate tissue of a dietary intervention. The first results of this study are supporting my research hypothesis. In fact, I have observed that the level of omega-3 in the prostate is associated with the progression towards a more aggressive stage of cancer. Specifically, the risk of progression towards a more aggressive PCa decreases with increasing prostate omega-3 content. I will continue to use this clinical study approach to determine if a particular type of omega-3 (EPA), can affect the PCa growth rate, inflammation and help increase the quality of life of PCa patients.

During the course of my clinical studies, with patients¿ consent, I have taken and stored prostate tissue samples. In a cell model taken from my bank of samples, I have observed that the level of inflammation produced by normal prostate cells is associated with the aggressiveness of the PCa found in the same patient. Furthermore, I use this cell model to study the effects of omega-3 on the expression of inflammatory genes.

By combining these approaches, I am building the basis for the development of new therapeutic avenues in PCa. One day, omega-3 could contribute to the treatment and prevention of PCa.