Le carcinome intracanalaire comme facteur pronostique du cancer de la prostate

 

Dominique Trudel

Centre hospitalier de l'Université de Montréal

 

Domaine : cancer

Programme chercheurs-boursiers cliniciens - Junior 1

Concours 2015-2016

Prostate cancer is the most frequent diagnosed cancer amongst men. For each diseased man, it is important to predict the outcome of the cancer as precisely as possible. By doing so, the man's physician can individualize the treatment, despite the very variable risk of progression from one man to the other. As of today, however, the tools allowing for such a prediction are not that useful.

When a pathologist analyses a prostate cancer under the microscope, he can identify either standard cancer or intraductal cancer. Intraductal cancer would be associated with a much poorer prognostic, but we don't know enough about this disease to use it to predict disease evolution in a single man.
 
As a pathologist-researcher, I am the best investigator to address this issue. I am therefore proposing two main projects. I first want to reliably quantify the prognostic effect of intraductal cancer. In order to do so, I will study prostates from a group of 1330 men followed during many years for their prostate cancer. This group is contemporary, is large and has been followed extensively, ensuring the value of the results. I also want to characterize intraductal cancer on many different aspects, from DNA to microscopic appearance. The objectives are many folds, but amongst other things I eventually wish to develop targeted therapies and to improve the detection of intraductal cancer. To answer my specific questions, I designed a research project that is rigorous, distinct and innovative.

Once my questions will have been answered, I hope we'll be able to help each man with prostate cancer by precisely individualizing his treatment.