La maîtrise de l'asthme à long terme, l'utilisation des ressources en santé, et leurs déterminants chez les enfants admis à l'unité des soins intensifs pour l'asthme


Sze Man Tse

Centre hospitalier universitaire Sainte-Justine


Domaine : santé circulatoire et respiratoire

Programme chercheurs-boursiers-cliniciens - Junior 1

Concours 2017-2018


AllerGen NCE

Asthma is a chronic lung disease affecting 1 out of 10 Canadian children. Of all children hospitalized for asthma flare-ups, a subgroup is admitted to the intensive care unit (ICU) for severe asthma flare-ups. While we know that these children are at higher risk of readmission for asthma, no one studied their symptoms control and the occurrence of milder flare-ups. Interestingly, studies suggest that American children are more frequently admitted to the ICU for asthma than Canadian children, although no one compared the 2 countries directly. Lastly, despite widespread asthma education, we need better ways for children to understand and take control of their asthma. Video games are new and attractive methods for promoting health and managing disease, but their role in childhood asthma has not been studied.

In my research program, I will carry out 3 projects to answer these questions. First, I will study the long-term outcomes of children with severe asthma, including their asthma symptoms control, quality of life, health resource use, and lung function, and to explore the mechanisms behind these poor outcomes by studying their clinical, inflammation, and genetic profiles. Second, I will compared the epidemiology of severe asthma in Canada and the US to better document the difference between the 2 countries and to gain insight on the reasons underlying these differences. Lastly, I will test an "app" that our team developed for children with asthma, aimed at improving their understanding of the disease and to encourage them to take their medication regularly.

We expect that the results of these projects will lead to a future multi-center North American study looking at further determinants of adverse long-term outcomes in these children, eventually leading to a personalized management, and to a clinical trial on the effectiveness of the app to control asthma symptoms in children.