L'obésité chez l'enfant: vers une meilleure compréhension de ses déterminants, de ses conséquences cardiométaboliques, des enjeux au niveau des habitudes de vie, et des stratégies novatrices de prévention et de prise en charge

 

Melanie Henderson

Centre de recherche du CHU Ste-Justine

 

Domaine : nutrition et métabolisme

Programme chercheurs-boursiers - Junior 1

Concours 2014-2015

One third of Canadian children are overweight or obese. The clinical and public health implications of childhood overweight and obesity are significant: these children tend to become obese adults, and are at-risk for cardiovascular disease and type 2 diabetes mellitus. Pre-diabetic conditions, such as impaired glucose tolerance and impaired fasting glucose are increasing in children, particularly obese children. The consequences of these increasing trends in abnormal sugar metabolism in youth are serious, considering the substantial illness and mortality associated with type 2 diabetes. Lifestyle interventions in adults have been shown to delay and even prevent the transition from pre-diabetes to full-blown diabetes. The impact of lifestyle habits on risk factors for type 2 diabetes in children remains largely unknown. Main goal: The main goal of my research program is to improve our understanding of the natural history and determinants of pre-diabetes in children, to better identify those most at risk of pre-diabetes, and increase knowledge leading to the development of early personalized preventive strategies.

I will study the Quebec Adipose and Lifestyle InvesTigation in Youth (QUALITY) Cohort, which will allow me to study 630 youth from childhood to late adolescence. I will use the information obtained from the QUALITY study to develop innovative interventions that I will then test within the CIRCUIT (Centre pédiatrique d'intervention en prévention et en réadaptation cardiovasculaires) program at CHU Ste-Justine, an avant-garde program that includes a novel physical activity intervention (Dyn@mo), a summer camp and after school program (starting in the fall 2013). The proposed studies will help clinicians identify those children most at risk of developing pre-diabetes, and help develop novel interventions that will serve to enhance clinical practice and community-based programs targeting at-risk youth.