L'influence du gène ApoE e4 sur les enfants d'âge préscolaire ayant subi un traumatisme cranio-cérébral


Dominique Dupont

Centre de recherche universitaire Sainte-Justine


Domaine : génétique humaine

Programme Formation de maitrise

Concours 2019-2020


Fondation des Étoiles

Young preschool children are particularly vulnerable to traumatic brain injury (TBI) because their brains are still under development. The consequences of TBI are numerous and can affect many areas of the child's life, including their mental and social skills. Most TBI studies in children focus exclusively on the effects of external factors (e.g. environment, socio-economic status, family resources) and clinical factors (e.g. severity of injury, symptoms) as predictors of the consequences of TBI. This research project aims to broaden our understanding of the elements that may contribute to the recovery from childhood TBI by studying the impact of genes on post-concussive symptoms. Specifically, this research will investigate the relationship between the presence of the ApoE e4 gene polymorphism on how the child recovers after the injury. In older children and adults with severe TBI, this gene is known to have an impact on recovery after TBI and place individuals at higher risk for cognitive deficits and poor emotional regulation.

This project is extremely innovative as it will be the first to study the effects of the ApoE e4 gene in preschool children who have acquired a mild TBI. This study will lead to a better understanding of the influence of genes on the recovery of post-concussive symptoms. Furthermore, this research is part of the "Kids' Outcomes and Long-term Abilities after Early Traumatic Brain Injury" (KOALA) project, which is being conducted in three large paediatric hospitals across Canada. The results of this project will contribute to improved management, follow-up and intervention following TBI early in a child's life.