L'atteinte rénale en grossesse : amélioration des outils diagnostiques et pronostiques

 

Anne-Marie Côté

Centre de recherche clinique Étienne-Le Bel du CHUS

 

Domaine : santé de la mère, des enfants et des adolescents

Programme chercheurs-boursiers cliniciens - Junior 1

Concours 2015-2016

High blood pressure during pregnancy is frequent. It occurs in 1 in 10 pregnancies. We diagnose ‘preeclampsia' when high blood pressure occurs along with other problems, such as too much protein spilling into the urine. Preeclampsia occurs in about 1 in 20 pregnancies. Preeclampsia is a major concern because it can lead to severe complications for mothers and their baby. For example, pregnant women can have seizures (eclampsia), or their baby can grow more slowly and can even die before birth, or be born too prematurely. The mothers' kidneys are affected in preeclampsia. This involvement  gives clues to the health caregivers that preeclampsia is arising or worsening. These clues can help to best manage pregnant women and their baby and avoid the severe complications of preeclampsia. This is why healthcare providers look for protein is the urine of women during their pregnancy visits. Currently, the tests used for proteins are not very good. There is a new test that detects cells detaching from the kidneys, named podocytes. We have the ability to measure podocytes in the urine at our research laboratory.

Our goal is to help health care providers detect mothers with kidneys already damaged by preeclampsia when the women present with high blood pressure but before the worrisome signs of preeclampsia (e.g. severe headache). In other words, our plan is to propose easy, quick and precise methods to measure proteins and podocytes in the urine of pregnant women who may have preeclampsia. Our hope is to detect more accurately and earlier preeclampsia before the severe complications occurs and to provide the most appropriate healthcare interventions to mothers and their babies.