L'apnée obstructive du sommeil dans la maladie de Parkinson : comprendre l'interaction et optimiser le traitement

 

Marta Kaminska

Institut de recherche du Centre universitaire de santé McGill

 

Domaine : santé circulatoire et respiratoire

Programme chercheurs-boursiers-cliniciens - Junior 2

Concours 2017-2018

Partenaire

Parkinson Québec

Parkinson's disease (PD) is the second most common neurodegenerative disease, and it increases with age. Sleep apnea is very common in the general population and also increases with age. It can affect the proper functioning of the brain. It could have a particularly harmful effect in people already suffering from a neurodegenerative disorder. The results of my preliminary research point to a two-way relationship between PD and sleep apnea: PD seems to favor obstructive sleep apnea, which in turn increases some symptoms of PD, especially excessive sleepiness and cognitive impairment.

The overall aim of my research program is to better understand the interaction between PD and sleep apnea, the goal being to reduce the burden of symptoms and improve quality of life for patients with PD.

Based on my preliminary findings, I initiated two randomized controlled trials (RCTs) to respond more fully to the questions raised, which form the base of my research program for the duration of the grant. The first project aims to assess the impact of treatment of sleep apnea on cognitive dysfunction and other clinical consequences in patients with PD suffering from sleep apnea. The second study evaluates the effect of long-acting levodopa, a typical treatment of PD, on the indices of sleep apnea as measured on a sleep study. These projects will advance our knowledge of the interaction between PD and sleep apnea and may suggest new treatment options improving the quality of life for many individuals.