Insulinorésistance et santé osseuse chez l'obèse : rôle des nutriments et des facteurs hormonaux

 

Claudia Gagnon

Centre de recherche du CHU de Québec-Université Laval

 

Domaine : nutrition et métabolisme

Programme chercheurs-boursiers-cliniciens - Junior 2

Concours 2017-2018

Obesity affects a growing number of Canadians. It predisposes to diseases including type 2 diabetes and cardiovascular disease. Except for weight loss, there is no specific nutritional recommendation to reduce risk of diabetes and cardiac disease in this population. This research program aims at determining whether consuming dairy products as well as taking vitamin D supplements, alone or in combination with fish proteins and omega-3 fatty acids, reduce risk of developing type 2 diabetes and cardiovascular disease in obese individuals. It also aims at evaluating whether genetically predisposed individuals better respond to these nutritional interventions.

In addition, contrary to the popular belief, obese individuals have bone fragility, increasing their risk of fracture. This research program will also look at the factors (in particular to the hormonal factors) influencing bone health in obese individuals. Moreover, it will assess the impact of weight loss strategies, including caloric restriction, liraglutide (a new medication recently approved for the treatment of obesity) and bariatric surgery, on bone health.